Fetal Immune Responses in Congenital Infection

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Abstract
The mammalian fetus generally enjoys a high degree of protection from infectious organisms in its isolated intrauterine environment, and is not often called upon to demonstrate its immunologic capabilities. But it is becoming increasingly apparent that immunologic maturation proceeds quietly during an appreciable portion of the gestational period in many species, including man, presumably in preparation for the time when the newborn infant will have to depend upon its own resources in a highly contaminated world.1 In addition to "tooling up" its immunologic potential, the developing organism is simultaneously turning off its capacity to respond to the antigens then present, . . .

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