IMPORTANCE OF RENAL PROSTAGLANDIN SYNTHESIS IN MAINTAINING RENAL BLOOD-FLOW AND GLOMERULAR-FILTRATION AFTER RENAL-ARTERY STENOSIS IN CONSCIOUS DOG

  • 1 January 1978
    • journal article
    • research article
    • Vol. 16  (1) , 72-74
Abstract
The effects of inhibiting prostaglandin synthesis on the renal blood flow and glomerular filtration rate of 4 conscious dogs with chronic unilateral renal artery stenosis was studied. Dogs were prepared by exteriorizing the bladder trigone to allow repeated split renal function studies. Renal artery stenosis was produced with a Goldblatt clamp on 1 renal artery. Each of 10 studies determined the function of each kidney in the conscious dog before and after indomethacin treatment. Indomethacin administration resulted in a 90% reduction of urinary prostaglandin E excretion, but no functional changes were produced in the kidney with the stenotic artery. Renal prostaglandins are apparently not responsible for maintenance of creatinine and p-aminohippuric acid clearances after renal artery stenosis in the dog. The concentration gradient for creatinine between the stenotic and non-stenotic kidney was enhanced by indomethacin.