Efficacy of Granulocyte–Macrophage Colony-Stimulating Factor in Acquired Alveolar Proteinosis
- 19 December 1996
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 335 (25) , 1924-1925
- https://doi.org/10.1056/nejm199612193352513
Abstract
Acquired alveolar proteinosis is a rare lung disease of adults characterized by excessive accumulation of surfactant.1 Standard therapy is whole-lung lavage, which usually provides temporary symptomatic benefit.1 In mice lacking the hematopoietic regulator granulocyte–macrophage colony-stimulating factor (GM-CSF), a pulmonary abnormality develops that resembles alveolar proteinosis.2,3 Therefore, we initiated a trial of recombinant human GM-CSF therapy in a patient with this disease after obtaining the approval of the institutional ethics committee and written informed consent from the patient.Keywords
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