Assignment of retinoblastoma susceptibility gene to mouse chromosome 14
- 1 September 1989
- journal article
- research article
- Published by Springer Nature in Somatic Cell and Molecular Genetics
- Vol. 15 (5) , 461-464
- https://doi.org/10.1007/bf01534896
Abstract
A human cDNA probe was used to screen a panel of mouse-Chinese hamster somatic cell hybrids to determine the chromosomal location of the retinoblastoma susceptibility gene (Rb-1)in mouse. The Rb-1gene mapped to mouse chromosome 14. Thus, the retinoblastoma susceptibility gene is syntenic with esterase 10 (the mouse homolog of human esterase D). The chromosomal assignment of the mouse Rb-1gene was further confirmed by using the same probe to study mouse-rat microcell hybrids. Since the human retinoblastoma susceptibility gene (RB1)along with the gene for esterase D is on chromosome 13q14, these data indicate this linkage group is conserved in man and mouse.Keywords
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