CONCENTRATIONS OF CEPHAPIRIN SODIUM IN PLASMA AND GYNECOLOGIC TISSUE AFTER A SINGLE PREOPERATIVE DOSE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 18  (2) , 92-96
Abstract
The penetration of cephapirin sodium into tissues that are commonly involved in gynecologic infections was studied after administration of a single i.v. dose of 1 g of cephapirin to .apprx. 15 patients to undergo gynecologic surgery. Blood and tissue specimens were obtained either 30 or 60 min after the infusion was completed. Blood levels averaged 16.07 .+-. 3.7 and 6.29 .+-. 1.6 .mu.g/ml and mean tissue levels were 7.87 and 6.28 .mu.g at the 2 sampling times, respectively. Bactericidal levels of cephapirin against sensitive organisms can be achieved in gynecologic tissues.

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