Symposium on Exoerythrocytic Forms of Malarial Parasites. II. A Search for Pre-Erythrocytic Stages of P. vivax and of P. cynomolgi

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Abstract
A presentation of methods and results of histologic examination of human and simian tissues previously inoculated with sporozoites of Plasmodium vivax and P. cynomolgi. Negative results were obtained in searching the tissues obtained in 38 biopsies of skin, lymph nodes, veins, bone marrow and muscle from 24 human volunteers inoculated with the salivary glands from 6 to 70 mosquitoes infected with P. vivax. Transplantation of areas of skin previously inoculated with sporozoites of P. vivax to susceptible volunteers failed to produce infection in the recipients of the grafts. The donors of the skin uniformly became infected. Microscopical search for pre-erythrocytic stages of P. vivax in organs of 5 spp. of monkeys revealed evidence of their presence in the liver of one rhesus monkey. At 48 hrs. these forms were segmenting. (Footnote No evidence was found of pre-erythrocytic stages of P. cynomolgi in organs of Macaca mulatta inoculated with sporozoites from 11 to 73 infected Anopheles quadrimaculatus and examined at intervals of 24, 50 and 72 hrs.).

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