Potential Antitumor Agents. XVII. Physalin B and 25,26-Epidihydrophysalin C From Witheringia coccoloboides
- 1 September 1981
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 44 (5) , 579-585
- https://doi.org/10.1021/np50017a013
Abstract
An investigation of W. coccoloboides (Dammer) A. T. Hunziker [Capsicum fuscoviolaceum (Cufodontis), Mort. and Standl.] roots resulted in the isolation of 2 cytotoxic compounds, physalin B and a novel physalin, which was characterized by spectral analysis as 25,26-epidihydrophysalin C. Both compounds have cytotoxic activity in 9KB [human nasopharyngeal carcinoma] and 9PS [mouse lymphocytic leukemia] tumor cells (in vitro). Physalin B has moderate activity against the 3PS mouse leukemia (in vivo).This publication has 1 reference indexed in Scilit:
- The structure of Physalins F and J from Physalis angulata and P. LancifoliaPhytochemistry, 1978