In vitro antiplaque properties of a series of alkyl bis(biguanides)

Publisher Website
Google Scholar
Abstract
A series of 8 alkyl bis(biguanide) analogues of alexidine, N,N''''''''-1,6-hexanediyl bis[N''-(2-ethylhexyl)imidodicarbonimidic diamide] (1), was prepared. Five of these analogues constituted a series isolipophilic with 1 but with varying bridge length between biguanide moieties. The compounds were evaluated in vitro for antibacterial and antiplaque properties against Streptococcus mutans, Actinomyces viscosus and A. naeslundii. One analogue, N,N''''''''-1,6-hexanediyl bis[N''-(n-octyl)imidodicarbonimidic diamide], appeared to be more effective than 1 or chlorhexidine against this spectrum of dental plaque forming microorganisms.

This publication has 1 reference indexed in Scilit: