Obstetrical and gynecological complications in fragile X carriers: A multicenter study
- 15 July 1994
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 51 (4) , 400-402
- https://doi.org/10.1002/ajmg.1320510419
Abstract
We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.Keywords
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