Effect of Potassium on the Movement of Water Across the Isolated Amphibian Skin

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Abstract
Share, L. and H. H. Ussing. Effect of potassium on the movement of water across the isolated amphibian skin. Acta physiol. scand. 1965. 64. 109–118. – Substitution of potassium for sodium in the Ringer bathing the inner surface of the isolated toad skin resulted in an increased net movement of water across the skin along an osmotic gradient. This effect was somewhat smaller than the response to vasopressin, although the responses to the high potassium treatment and to vasopressin were not additive. Substitution of sulfate for chloride as the major anion in the Ringer did not modify the relative increase in water movement following either the potassium or vasopressin treatments, although the magnitude of the water movements were greater with the latter anion. Low pH blocked the response to vasopressin but not to potassium. Changes in the concentration of calcium in either inner or outer solutions were without effect on the responses to either potassium or vasopressin. Parallel seasonal changes in the responsiveness of the toad skin to potassium and vasopressin were ohserved.