Application of Live Varicella Vaccine to Children with Acute Leukemia or Other Malignancies Without Suspension of Anticancer Therapy

Abstract
A live varicella vaccine was given to children with acute leukemia or other malignancies with minimal clinical reactions.1 In that study, anticancer medication was suspended beginning one week before vaccination and was not resumed until one week after vaccination. In the present study, we attempted to vaccinate such children without suspension of anticancer medication. SUBJECTS AND METHODS Fifteen children with acute leukemia, 12 children with malignant solid tumors (4 neuroblastoma, 4 retinoblastoma, 2 Wilms tumor, 2 teratocarcinoma), and 1 child with lymphosarcoma received a live varicella vaccine1 (500 plaque forming unit/dose) without suspension of anticancer medication. All of these children had been in remission.

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