Bioreversible protection for the phospho group: chemical stability and bioactivation of di(4-acetoxybenzyl) methylphosphonate with carboxyesterase
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 875-877
- https://doi.org/10.1039/c39910000875
Abstract
In contrast to high chemical stability (t1/2 55.4 h at 36.4 °C), with porcine liver Carboxyesterase the title compound 1 spontaneously decomposes first to the monoester 2 then to methylphosphonate, both reactions proceeding via the 4-hydroxybenzyl intermediates 3 and 4.Keywords
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