EXCRETION OF 17-KETOSTEROIDS BY MALE RABBITS DURING ALTERED GONADAL FUNCTION

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Abstract
By standardization of environmental conditions and selection of animals for such variables as health, weight, age, nutrition, it is possible to control factors which have been indicated as influencing the excretion of 17-ketosteroids (Landau et al., 1948; Forbes et al., 1947). Proper use of such controls should provide opportunity for critical investigations of 17-ketosteriod metabolism. Relatively few studies have reported the urinary 17-ketosteriod excretion in laboratory animals. They have been assayed in the rat (Lampton and Miller, 1941), mouse (Karnofsky et al., 1944), chimpanzee (Dorfman et al., 1947), and rabbit (Kimeldorf, 1948). Unfortunately, values reported by these investigators are not strictly comparable because of differences in assay techniques. The purpose of the present investigation is to study alterations in 17-ketosteroid excretion experimentally induced in rabbits whose normal excretion level has been established. materials and methods Data reported in these investigations were derived from the study of 20 New Zealand Albino male rabbits. All were sexually mature and weighed 9.5–12.5 pounds with only three animals weighing more than 11.5 pounds.

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