Effects of recombinant human interleukin‐1β on rabbit articular chondrocytes
Open Access
- 1 October 1988
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 31 (10) , 1290-1296
- https://doi.org/10.1002/art.1780311011
Abstract
Using an in vitro model, we characterized the production of prostaglandin E2, 6‐keto‐prostaglandin F1α, and thromboxane B2 by normal rabbit articular chondrocytes stimulated by interleukin‐1β. The prostanoids were produced in a dose‐ and time‐dependent manner, which was sensitive to actinomycin D and cycloheximide. Interleukin‐1 also had a pronounced, but reversible, cytostatic effect on chondrocytes, which was not attributable to prostanoid or polyamine synthesis.This publication has 33 references indexed in Scilit:
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