Transforming growth factor alpha inhibits secretion of gastric acid.

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Abstract
Transforming growth factor .alpha. (TGF-.alpha.), a protein secreted by transformed cells and related to epidermal growth factor (EGF), was tested for its effects on gastric acid secretion. Guinea pig gastric mucosae were mounted to Ussing chambers and the rate of acid release was monitored by the pH-stat method. When administered prior to the secretagogue, TGF-.alpha. prevented the histamine-induced increase in the rate of acid secretion. Similarly, TGF-.alpha. caused a decrease in the rate of acid release in tissues that had already been stimulated with histamine. These data show that TGF-.alpha. inhibits gastric acid secretion in a manner similar to EGF and that the two growth factors share at least one physiological action unrelated to their mitogenic properties.