ALLELE LOSSES ON CHROMOSOME-17 IN HUMAN EPITHELIAL OVARIAN-CARCINOMA

  • 1 October 1990
    • journal article
    • research article
    • Vol. 5  (10) , 1599-1601
Abstract
16 epithelial ovarian carcinomas (12 serous, 2 mucinous and 2 endometrioid) and 2 benign ovarian adenomas were studied using recombinant DNA technology to compare loci on chromosome 17 in germ-line and tumor DNA. Four polymorphic probes mapping to 17p and one mapping to 17q were used. There was a high frequency of allele loss on 17q (77%) and a slightly lower frequency on 17p (69%). These findings probably indicate loss of tumor suppressor genes which are of fundamental importance in the genesis or progression of epithelial ovarian carcinomas.

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