Clonal analysis of morphological phenotype in cultured mammary epithelial cells from human milk

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Abstract
Three main types of colony forming epithelial cells, termed elongated, cuboidal and open, are found in cultures of human milk. Subculture of identified colonies, and cloning from single cells shows that each cell type can maintain its morphological phenotype, but the cuboidal and open cell types can also give rise to the elongated type. A differentiation pathway, starting with open cell types, is suggested and discussed in relation to differentiation studies on mammary cancer cells.