THE EFFECT OF 10-PERCENT AND 20-PERCENT SAFFLOWER OIL EMULSION GIVEN AS 30-PERCENT TO 50-PERCENT OF TOTAL CALORIES

  • 1 January 1983
    • journal article
    • research article
    • Vol. 156  (4) , 433-438
Abstract
In a prospective study of 7 patients undergoing operations, 10 and 20% safflower oil emulsions were safe and effective as a major component of adult parenteral nutrition. Clinically important adverse effects of the emulsions as monitored by clinical evaluation and screening hematologic and blood chemistry determinations were not identified. An extensive coagulation profile in these patients has failed to identify procoagulant effects of parenteral safflower oil. The optimum dosage of fat for a balanced parenteral diet is not known. Linoleic acid administered as 4% of total calories every other day will treat or prevent essential fatty acid deficiency, and this dosage may be considered a minimum requirement for parenteral fat. Parenteral safflower oil administered as 30-50% of total calories is effective in achieving N balance. Fat emulsions today allow the use of parenteral diets that match the normal diet consumed orally in terms of the balance of protein, carbohydrate and fat.

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