Effect of Chlorpromazme on Survival Time in Irradiated Mice.

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Abstract
Pre-medication with 5 mg/kg of chlorpromazine (10-(3-dimethyl amino propyl)-2-chlorphenothiazine) intraperitoneally significantly increased the mean survival time in irradiated mice. Post-irradiation medication with this dose of drug was neither beneficial nor detrimental but doses of 10 and 20 mg/kg decreased survival time by acting synergistically with the irradiation. The sensitivity of the irradiated animals to medication was discussed.