The Efficacy of Penicillin Regimens

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Abstract
Phenethicillin given orally was found to be an effective agent in the treatment of respiratory tract infections due to pneumococci and beta hemolytic streptococci. Bacteriological superinfection was infrequent in patients treated with 2.4 million units or less of intramuscular aqueous or procaine penicillin G or with oral potassium phenethicillin, 250 mg every six hours. If the dosage of potassium phenethicillin was increased to 500 mg every six hours by mouth, or if 10 million to 20 million units of aqueous or procaine penicillin G was given intravenously, the superinfection rate rose 25% to 28.6%. Forty per cent of those bacteriologically superinfected incurred clinical disease attributed to the superinfection. These studies emphasize that the most advantageous regimen for patients with acute pulmonary infections consists of the smallest amount of a single antibiotic that will suppress or eradicate invading microorganisms.

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