Effects of glucose-insulin-potassium infusion on myocardial infarction and myocardial blood flow following experimental coronary artery occlusion.

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Abstract
To determine the therapeutic effects of glucose-insulin K (GIK) solution, 5 control dogs and 5 GIK-treated dogs were investigated 24 h after coronary artery occlusion by use of myocardial creatine phosphokinase (CK) activity and myocardial 201 Tl uptake. There was no significant difference in myocardial blood flow estimated by 201 Tl uptake between the control and the GIK group, but myocardial CK activity in the ischemic zone of GIK-treated animals was significantly higher than that of the control group. Administration of GIK solution apparently is effective in protecting myocardial tissue in the central ischemic area. This protecting action of GIK seems to be independent of myocardial blood flow.