Some observations on the β‐adrenoceptor agonist properties of the isomers of salbutamol

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Abstract
1 The pharmacological activities of the optical isomers of salbutamol have been examined. (–)-Salbutamol was much more potent than (+)-salbutamol on β-adrenoceptors. 2 Both (–)- and (+)-salbutamol showed high selectivity for β-adrenoceptors in bronchial muscle compared to cardiac muscle, in this way resembling racemic salbutamol. 3 The use of isomeric activity ratio to detect differences between receptors was examined in the light of the results obtained with the isomers of salbutamol.