Therapeutic applications of polymeric artificial cells
- 1 March 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Drug Discovery
- Vol. 4 (3) , 221-235
- https://doi.org/10.1038/nrd1659
Abstract
Polymeric artificial cells have the potential to be used for a wide variety of therapeutic applications, such as the encapsulation of transplanted islet cells to treat diabetic patients. Recent advances in biotechnology, molecular biology, nanotechnology and polymer chemistry are now opening up further exciting possibilities in this field. However, it is also recognized that there are several key obstacles to overcome in bringing such approaches into routine clinical use. This review describes the historical development and principles behind polymeric artificial cells, the present state of the art in their therapeutic application, and the promises and challenges for the future.Keywords
This publication has 108 references indexed in Scilit:
- In Vitro Maturation of Neonatal Porcine IsletsAnnals of the New York Academy of Sciences, 2006
- Clinical features and management of herb-induced aconitine poisoningAnnals of Emergency Medicine, 2004
- Microencapsulated iNOS‐expressing cells cause tumor suppression in miceThe FASEB Journal, 2001
- Transplantation of Pancreatic Islets Contained in Minimal Volume Microcapsules in Diabetic High MammaliansAnnals of the New York Academy of Sciences, 1999
- Pharmacological evaluation of portal venous isolation and charcoal haemoperfusion for high-dose intra-arterial chemotherapy of the pancreasBritish Journal of Surgery, 1997
- Characterization of free and alginate–polylysine–alginate microencapsulated Erwinia herbicola for the conversion of ammonia, pyruvate, and phenol into L‐tyrosineBiotechnology & Bioengineering, 1995
- Kinetic Analysis of UDP‐Glucuronosyltransferase in Bilirubin Conjugation by Encapsulated Hepatocytes for Transplantation into Gunn RatsArtificial Organs, 1995
- Nylon polyethyleneimine microcapsules for immobilizing multienzymes with soluble dextran-NAD+ for the continuous recycling of the microencapsulated dextran-NAD+Biochemical and Biophysical Research Communications, 1978
- Formation of amino acid from urea and ammonia by sequential enzyme reaction using a microencapsulated multi-enzyme systemBiochemical and Biophysical Research Communications, 1977
- Stablisation of enzymes by microencapsulation with a concentrated protein solution or by microencapsulation followed by cross-linking with glutaraldehydeBiochemical and Biophysical Research Communications, 1971