Genetic and Epigenetic Alterations in the von Hippel-Lindau Gene: the Influence on Renal Cancer Prognosis
Open Access
- 1 February 2008
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 14 (3) , 782-787
- https://doi.org/10.1158/1078-0432.ccr-07-1753
Abstract
Background: Inactivation of the von Hippel-Lindau (VHL) gene is considered as an early event in renal cancer tumorigenesis. The prognostic relevance of these changes, however, is not clear and previous results are contradictory. We have evaluated the influence of (epi)genetic alterations in VHL on cause-specific survival in clear-cell renal cell cancer (ccRCC) in a large, population-based group of cases.Keywords
This publication has 30 references indexed in Scilit:
- Is Molecular Profiling Ready for Use in Clinical Decision Making?The Oncologist, 2007
- Estimates of the cancer incidence and mortality in Europe in 2006Annals of Oncology, 2007
- Current status and future directions of molecular markers in renal cell carcinomaCurrent Opinion in Urology, 2006
- Cigarette smoking, von Hippel–Lindau gene mutations and sporadic renal cell carcinomaBritish Journal of Cancer, 2006
- Molecular BiasEuropean Journal of Epidemiology, 2005
- Why Most Published Research Findings Are FalsePLoS Medicine, 2005
- VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinomaThe Journal of Pathology, 2001
- Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinomaBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1996
- Mutations of the VHL tumour suppressor gene in renal carcinomaNature Genetics, 1994
- Development of a Record Linkage Protocol for Use in the Dutch Cancer Registry for Epidemiological ResearchInternational Journal of Epidemiology, 1990