A HISTOLOGICAL AND CHEMICAL STUDY OF THREE CASES OF DIFFUSE CEREBRAL SCLEROSIS

Abstract
In the "spongy type" (Canavan) of diffuse cerebral sclerosis, chemical findings suggested an arrest of myelinization of cerebral white matter during late fetal life. In the Pelizaeus-Merzbacher type, probable arrest of myelinization in early childhood with recent cortical degeneration was indicated. In a Krabbe-type case "globoid bodies" contained cerebroside which had excited a microglial reaction.