Responses of Liver Lipid Fractions, Liver and Plasma Electrolytes Shortly After Alloxan Administration in Rat

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Abstract
The responses of the liver, and liver and plasma electrolytes to alloxan administration were determined at 4, 24, and 72 hours. Adrenal ascrobic and cholesterol concentrations were also measured as indices of adrenocortical activation in these animals. Besides the known responses of hyperglycemia and decreased liver glycogen content there were changes in liver lipid fractions and electrolytes, and plasma electrolytes in all groups given alloxan. Most conspicuous alterations were an increased liver neutral fat and decreased K content, and increased plasma K levels in all alloxan-injected groups. In the 24 and 72 hour groups there were increased liver phospholipids and increased Na, and decreased plasma Na in addition to other tissue changes. The changes in the 4 and 24 hour groups after alloxan are discussed as signs of an hepatotoxic action of alloxan, or responses of a stress type which are adrenocortically conditioned. The nature of the altered chemistries 72 hours after alloxan were essentially the same as in adrenal-demedullated rats.