Effect of 6-Dimethylaminopurine-3-Amino-D-Ribose on Adenosine Triphosphate Formation in Yeast.

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Abstract
It was demonstrated that 6-dimethylamino-purine-3-amino-d-ribose (Aminonucleoside) induces the nephrotic syndrome in rats. In an effort to obtain evidence of the mechanism of production of this experimental nephrosls, the effect of this compound on adenosine metabolism was investigated. A brewer''s yeast was studied which converted adenosine to ATP on incubation in a phosphate buffer. By chemical analysis, by enzymatic analysis, and by chromatography the Aminonucleoside inhibited the formation of ATP in such systems. The implications of this anti-metabolite effect with regard to the patho-genesis of renal disease are not yet apparent.