Synthesis and biological actions of 2-substituted quinolizidines
- 1 January 1976
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (1) , 122-126
- https://doi.org/10.1021/jm00223a021
Abstract
A series of 2-substituted quinolizidines was synthesized and tested for their effects on motor activity in mice. In the 2-aryl-2-hydroxyquinolizidines (5 and 6) a difference was noted in potency between the axial and equatorial aryl analogs. A significant difference in activity was also found between the epimeric 2-(4-fluorobenzoyl) quinolizidines (10c and 11c).Keywords
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