Clonal Origin of Bladder Cancer
Open Access
- 12 March 1992
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 326 (11) , 737-740
- https://doi.org/10.1056/nejm199203123261104
Abstract
Patients with cancer of the urinary bladder often present with multiple tumors, appearing at different times and at different sites in the bladder. This observation has been attributed to a "field defect" in the bladder that allows the independent transformation of epithelial cells at a number of sites. We tested this hypothesis using molecular genetic techniques.Keywords
This publication has 25 references indexed in Scilit:
- Evolution of the X chromosomeNature, 1990
- Mutations in the p53 gene occur in diverse human tumour typesNature, 1989
- Preferential germline mutation of the paternal allele in retinoblastomaNature, 1989
- Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcomaNature, 1989
- The Molecular Genetics of Philadelphia Chromosome–Positive LeukemiasNew England Journal of Medicine, 1988
- Genetic Alterations during Colorectal-Tumor DevelopmentNew England Journal of Medicine, 1988
- Monoclonality and Abnormal Parathyroid Hormone Genes in Parathyroid AdenomasNew England Journal of Medicine, 1988
- The Molecular Genetics of CancerScience, 1987
- Loss of genes on the short arm of chromosome 11 in bladder cancerNature, 1985
- Immunoglobulin-Gene Rearrangements as Unique Clonal Markers in Human Lymphoid NeoplasmsNew England Journal of Medicine, 1983