HORMONAL AND ULTRASTRUCTURAL OBSERVATIONS IN A CASE OF RESISTANT OVARY SYNDROME

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Abstract
Hormonal and ultrastructural findings in a 21 yr old woman with secondary amenorrhea were described in detail. The subject fulfilled all the criteria necessary to establish the diagnosis of resistant ovary syndrome. Ovarian biopsies revealed numerous primordial and primary follicles, which showed a normal morphology by light microscopy and EM. The follicles could not be stimulated by large doses of human gonadotropins alone or by simultaneous administration of cortisone acetate and large doses of human gonadotropins. The association of a decreased target cell response with increased levels of serum FSH [follitropin] and LH [lutropin] may be explained in different ways. The presence of an inhibitor preventing the normal action of gonadotropins could not be substantiated, because circulating gonadotropin antibodies were not detected. The serum prolactin level was normal.