UNUSUAL PROPERTIES OF HYALURONATEPROTEIN ISOLATED FROM PATHOLOGICAL SYNOVIAL FLUIDS*

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Abstract
A compound of hyaluronate and protein (HP) isolated from synovial effusions in rheumatoid arthritis or gout showed unusual properties that distinguished it from normal HP. The HP from pathological effusions contained more protein (about 10%); remained immobilized at the origin during zone electrophoresis at pH 4.5; and formed a gel during dialysis in acetate buffer, pH 4.5. The integrity of both the hyaluronate and protein moieties was required for electrophoretic immobility and gel formation.