Idiotypy of Measles Virus Nucleocapsid‐Specific IgGχ Antibody in Serum and Cerebrospinal Fluid in Subacute Sclerosing Panencephalitis

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Abstract
A gel-precipitating anti-idiotypic antiserum was prepared in a rabbit by immunization with measles virus-specific IgG isolated from the serum of a patient with subacute sclerosing panencephalitis (SSPE). The idiotypic determinant was associated with an electrophoretically restricted sod cathodally migrating IgGχ protein in serum and cerebrospinal fluid (CSF), with antibody activity to measles nucleocapsids. The anti-idiotypic antiserum did not precipitate with other oligoclonal populations of measles-specific IgG in the patient's serum or CSF, nor with serum or C5F from 4 other patients with SSPH and 10 patients with multiple sclerosis.