The Interference by Japanese Encephalitis Virus with Newcastle Disease Virus in Vero Cells

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Abstract
Vero cells defective in the production of interferon were used to investigate the role of interferon in the induction of the interference by Japanese encephalitis virus with Newcastle disease virus. Vero cells infected with Japanese encephalitis virus became refractory to superinfection with Newcastle disease virus but not to vesicular stomatitis virus or vaccinia virus. Interference was not induced when cells were pretreated with puromycin. The interference in Vero cells differed from that observed in other cells in that the induction occurred late in infection with the interfering virus rather than early, and the interference was markedly inhibited by trypsinizing the infected monolayers. The data indicated that the interference in Vero cells was not mediated by interferon but rather by unstable protein(s) produced during the replication of the interfering virus. Some, but not all, of the arboviruses examined induced this type of interference in Vero cells.

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