ONSET OF CELL-PROLIFERATION IN SHORTENED GUT - COLONIC HYPERPLASIA AFTER ILEAL RESECTION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 72  (2) , 263-266
Abstract
Cytokinetics in colonic mucosa were studied after ileal resection in young female rats. The RNA content of the transverse colon was increased 32% after 7 days; after 14 days the increase was present throughout the colon. The DNA content of the ascending colon increased 29% after 10 days. Specific activity of DNA labeled with [3H-methyl]thymidine was elevated 29% in the ascending colon and elevated 49% in the descending colon on the 7th postoperative day. Colonic cell proliferation was stimulated within 1 wk of ileal resection.