Hanganutziu-Deicher Antigen and Antibody in Pathologic Sera and Tissues
Open Access
- 1 June 1979
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 122 (6) , 2314-2318
- https://doi.org/10.4049/jimmunol.122.6.2314
Abstract
Heterophile, Hanganutziu-Deicher (H-D) antigen was studied in pathologic sera by means of inhibition of agglutination of bovine erythrocytes by H-D antibodies. H-D antigen was demonstrated in 38% of random cancer sera, 25% of lymphoma or leukemia sera, 25% of leprosy sera, 8% of infectious mononucleosis sera, 6% of rheumatoid arthritis sera, and 27% of synovial fluids of rheumatoid arthritis patients. None of 134 normal human sera gave positive results. Some of the inhibition-positive cancer sera formed precipitation lines with H-D antibody-containing sera. Over 50% of various extracts of cancer tissues as well as spleens of lymphoma or leukemia patients were shown to contain H-D antigen by means of the inhibition test.Keywords
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