The C. elegans methionine aminopeptidase 2 analog map‐2 is required for germ cell proliferation
- 18 September 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 576 (1-2) , 245-250
- https://doi.org/10.1016/j.febslet.2004.08.077
Abstract
We have investigated the physiological function of type 2 methionine aminopeptidases (MetAP2) using Caenorhabditis elegans as a model system. A homolog of human MetAP2 was found in the C. elegans genome, which we termed MAP-2. MAP-2 protein displayed methionine aminopeptidase activity and was sensitive to inhibition by fumagillin. Downregulation of map-2 expression by RNAi led to sterility, resulting from a defect in germ cell proliferation. These observations suggest that MAP-2 is essential for germ cell development in C. elegans and that this ubiquitous enzyme may play important roles in a tissue specific manner.Keywords
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