Physical Chemistry of Contractile Process in Muscle

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Abstract
The physicochemical model of the contractile process in muscle, previously used for the interpretation of the mechanical and thermal behavior of muscle, is used to estimate the mol. wt. of the contractile unit. The value, 43,000, obtained from the kinetics of the reactions of the contractile unit, is in fair agreement with the value, 60,000, obtained from the heat evolved per twitch. Within the accuracy of the available data these values are consistent with Riseman and Kirkwood''s theory of the elastic modulus of muscle and with Szent-Gyorgyi''s estimate of the size of the "autone." X-ray , electron microscope, and chemical evidence is cited in support of the assumption that muscle myosin consists of macromolecular sub-units.
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