Differential Antigen Presentation Kinetics of CD8+T-Cell Epitopes Derived from the Same Viral Protein
- 15 September 2008
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 82 (18) , 9293-9298
- https://doi.org/10.1128/jvi.00749-08
Abstract
The kinetics of peptide presentation by major histocompatibility complex class I (MHC-I) molecules may contribute to the efficacy of CD8+ T cells. Whether all CD8+ T-cell epitopes from a protein are presented by the same MHC-I molecule with similar kinetics is unknown. Here we show that CD8+ T-cell epitopes derived from SIVmac239 Gag are presented with markedly different kinetics. We demonstrate that this discrepancy in presentation is not related to immunodominance but instead is due to differential requirements for epitope generation. These results illustrate that significant differences in presentation kinetics can exist among CD8+ T-cell epitopes derived from the same viral protein.This publication has 20 references indexed in Scilit:
- Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 ReplicationJournal of Virology, 2007
- Portable flanking sequences modulate CTL epitope processingJournal of Clinical Investigation, 2007
- Pol-Specific CD8 + T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I DownregulationJournal of Virology, 2007
- Recognition of a Defined Region within p24 Gag by CD8+T Cells during Primary Human Immunodeficiency Virus Type 1 Infection in Individuals Expressing Protective HLA Class I AllelesJournal of Virology, 2007
- Epitope-Dependent Avidity Thresholds for Cytotoxic T-Lymphocyte Clearance of Virus-Infected CellsJournal of Virology, 2007
- HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1PLoS Medicine, 2006
- Extraepitopic Compensatory Substitutions Partially Restore Fitness to Simian Immunodeficiency Virus Variants That Escape from an Immunodominant Cytotoxic-T-Lymphocyte ResponseJournal of Virology, 2004
- Impacts of Epitope Expression Kinetics and Class I Downregulation on the Antiviral Activity of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T LymphocytesJournal of Virology, 2004
- The Influence ofHLAGenotype on AIDSAnnual Review of Medicine, 2003
- HIV-1 Gag Proteins: Diverse Functions in the Virus Life CycleVirology, 1998