Effect of Tolbutamide on Renal Glucose Reabsorption

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Abstract
In sixteen patients, thirteen examinations were carried out after intravenous administration of 1 g of tolbutamide, including measurements of inulin clearance and glucose TmG before and after administration. Furthermore, 4 examinations were performed with administration of 1 g of tolbutamide daily over periods from fourteen days to 160 days. No alterations in inulin clearance were found. The changes in glucose TmG presented fairly large individual variations and increases between 20 and 30 per cent were observed in a few patients. An average increase of 9. 1% was found after intravenous administration and of 4. 8% after oral administration. These variations are not significant.

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