AUTOANTIBODIES TO DUODENAL GASTRIC-INHIBITORY-PEPTIDE (GIP) CELLS AND TO SECRETIN (S) CELLS IN PATIENTS WITH CELIAC-DISEASE, TROPICAL-SPRUE AND MATURITY-ONSET DIABETES

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (1) , 33-42
Abstract
The presence of autoantibodies detected by immunofluorescence [IFL] to single endocrine cells of human duodenum is described in 3 groups of patients and 2 control groups. Of 173 celiac cases, 4 had GIP [gastric-inhibitory-peptide] cell antibodies, 1 had secretin cell antibodies and 21 reacted with both cell types. Of 12 tropical sprue sera, 4 reacted with the same 2 cells. Among 50 elderly diabetics treated with hypoglycemic drugs, 7 sera gave a positive cytoplasmic IFL on duodenal substrate. Four were identified as GIP cells by use of the appropriate hormone antiserum and 3 reactions were against cells distinct from those stained by anti-GIP, -secretin, -somatostatin, -glucagon and -gastrin. Additional gut hormone antisera must be tested to identify these APUD cells. Thirty blood donors and 73 sera from autoimmune endocrine patients gave entirely negative results on unfixed cryostat sections of duodenal mucosa. Although impaired GIP and secretin responses were reported in celiac disease and abnormal GIP values were found in Type II diabetes, there is as yet no data to correlate these metabolic dificiencies with the presence of endocrine cell antibodies in the serum.