Spectrophotometric determination of clioquinol and diodoquin in pharmaceutical preparations using uranyl acetate as a chromogenic agent
- 1 January 1988
- journal article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 113 (11) , 1653-1655
- https://doi.org/10.1039/an9881301653
Abstract
Simple spectrophotometric methods for the determination of clioquinol and diodoquin in pharmaceutical preparations, based on the measurement of the intensity of the yellow-orange colour produced by the reaction of clioquinol or diodoquin with uranyl acetate in N,N-dimethylformamide (DMF) medium have been developed. The yellow-orange complex has an absorption maximum at 394 nm with molar absorptivities of 0.36 × 103 and 0.41 × 103 l mol–1 cm–1 for clioquinol and diodoquin, respectively. The method is best suited to the determination of 0–175 and 0–225 µg ml–1 of clioquinol and diodoquin, respectively.Keywords
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