Insect Developmental Inhibitors: A Practical Evaluation as Mosquito Control Agents12

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Abstract
The term, “;insect developmental inhibitor,” is proposed to describe compounds having biological activity that mimics that of natural insect juvenile hormones and that are being evaluated as insect control agents. There was much greater variation in mortality between replicate tests run at different times than is typical for classical insecticides. The sensitivity of larvae to a given compound varied with age in the 4th stage; the earlier larval stages were less sensitive than the 4th. Several compounds produced very high mortality in both laboratory and field evaluations. ZR515 (isopropyl 1I-methoxy-3,7,1I-trimethyl-2,4-dodecadienoate), had a high degree of activity on Aedes nigromaculis (Ludlow) larvae at 0.00001 ppm in the laboratory and gave encouraging results at 0.125 lb/acre in the field. R020-3600 (6,7-epoxy-3-methyl-7-ethyl-l-[3-4-(methylenedioxy)phenox y]-2-cistrans-octene), also showed high activity in the laboratory and in the field with the same species at rates as low as 0.25 lb/acre. MON-585 (2,6-di-tert-butyl-4-(α,α-dimethylbenzy) phenol), whose structure is dissimilar to known natural insect hormones, gave excellent control of A. nigromaculis larvae in field tests where 1.5 or 2.0 lb/acre were applied by helicopter.

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