Survival differences related to estrogen receptor beta (ERβ) polymorphism and age in female patients with metastatic colon cancer
- 15 July 2004
- journal article
- abstracts
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 22 (14_suppl) , 3618
- https://doi.org/10.1200/jco.2004.22.14_suppl.3618
Abstract
3618 Background: Estrogen replacement therapy decreases the risk of colon cancer in postmenopausal women. ERβ, not ERα, is expressed in the colon. ERβ function in colon tissue has been linked with tumor development, apoptosis and prognostic markers. ERβ gene contains a polymorphic dinucleotide CA repeat in the 3' noncoding region which is associated with hormone levels in females. Analysis was done on metastatic colon cancer patients to determine: 1) Whether ERβ polymorphism are associated with survival 2) if a difference in survival between young (pre-menopausal) and old (post-menopausal) patients exists. Methods: A population of 388 patients with metastatic colon cancer collected from 1997 to 2003 was selected for by age. The age extremes were selected because estrogen levels were important for this study and menopause will affect hormone levels. 29 patients of young age (65 years) there were 82 patients, 33 po...Keywords
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