Tobacco Chemistry. 54. (1S,2E,4S,6E,8S,11R,12S)-8,11-Epoxy-2,6-cembradiene-4,12-diol, a New Constituent of Greek Tobacco.

Abstract
A new diterpenoid was isolated from Greek tobacco and is formulated as (1S,2E,4S,6E,8S,11R,12S)-8,11-epoxy-2,6-cembradiene-4,12-diol by spectroscopic methods, synthesis and X-ray analysis of its 4R-epimer. The biogenesis of the diol is discussed on the basis of results obtained from epoxidation and rearrangement reactions.

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