Lysozyme: primary bactericidin in human plasma serum active against Bacillus subtilis

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Abstract
The in vitro bactericidal reaction of human plasma serum against B. subtilis was investigated. Human lysozyme was purified to homogeneity and antiserum was prepared against the enzyme. The anti-lysozyme immunoglobulin G was used as a specific inhibitor in bactericidal and bacteriolytic reactions. At low serum concentrations lysozyme was the primary bactericide active against B. subtilis. At appreciably higher serum concentrations, a lysozyme-independent bactericidal activity was also demonstrated.