Imaging of pulmonary disease in scleroderma with J001X scintigraphy.
Open Access
- 1 May 1994
- Vol. 49 (5) , 504-508
- https://doi.org/10.1136/thx.49.5.504
Abstract
BACKGROUND--J001X is an acylated poly-galactoside isolated from the membrane of Klebsiella and able to interact with macrophages, mainly in their activated state. The aim of the present study was to determine the ability of 99m-labelled technetium (99mTc)-J001X scintigraphy to image pulmonary disease, defined by high resolution computed tomographic scanning and pulmonary function tests, in patients suffering from scleroderma. METHODS--Patients were considered to have pulmonary disease when they had at least two positive signs on high resolution computed tomography, or a decrease in lung volume and single breath carbon monoxide transfer, or both, with no disease process other than scleroderma in their medical history. Positive J001X scintigraphic imaging was defined by symmetrical bilateral pulmonary fixation three and five hours after inhalation of 99mTc-J001X. J001X scintigraphic results were compared with disease activity as indicated by bronchoalveolar lavage (BAL) fluid lymphocytosis. RESULTS--Seventeen patients were studied, in 12 of whom J001X scintigraphy was positive. There was no correlation between BAL lymphocytosis and J001X scintigraphic findings, nor between BAL and pulmonary scleroderma. This was not surprising because of the high specificity of macrophage targeting by J001X. CONCLUSIONS--Follow up of a larger population over a longer period is needed to establish whether there is a prognostic value for positive J001X scintigraphic findings in scleroderma.Keywords
This publication has 27 references indexed in Scilit:
- Scintigraphy with J001X, a Klebsiella membrane glycolipid, for the early diagnosis of chronic berylliosis: results from an experimental model.Occupational and Environmental Medicine, 1992
- Evidence for protein oedema, neutrophil influx, and enhanced collagen production in lungs of patients with systemic sclerosis.Thorax, 1990
- Evaluation and management of scleroderma lung disease using bronchoalveolar lavageThe American Journal of Medicine, 1990
- SPONTANEOUS PRODUCTION OF FIBRONECTIN BY ALVEOLAR MACROPHAGES IN PATIENTS WITH SCLERODERMAArthritis & Rheumatism, 1989
- Pulmonary involvement in systemic sclerosis: the detection of early changes by thin section CT scan, bronchoalveolar lavage and 99mTc-DTPA clearanceRespiratory Medicine, 1989
- Activated alveolar macrophages in subclinical pulmonary inflammation in collagen vascular diseases.Thorax, 1988
- Interstitial lung disease in scleroderma analysis by bronchoalveolar lavageArthritis & Rheumatism, 1984
- 67Gallium lung scans in progressive systemic sclerosisArthritis & Rheumatism, 1983
- Serial pulmonary function tests in progressive systemic sclerosis.Thorax, 1979
- Minor salivary gland involvement in Sjögren's syndromeOral Surgery, Oral Medicine, Oral Pathology, 1974