RNA III Inhibiting Peptide Inhibits In Vivo Biofilm Formation by Drug-Resistant Staphylococcus aureus
- 1 June 2003
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (6) , 1979-83
- https://doi.org/10.1128/aac.47.6.1979-1983.2003
Abstract
Staphylococcus aureus is a prevalent cause of bacterial infections associated with indwelling medical devices. RNA III inhibiting peptide (RIP) is known to inhibit S. aureus pathogenesis by disrupting quorum-sensing mechanisms. RIP was tested in the present study for its ability to inhibit S. aureus biofilm formation in a rat Dacron graft model. The activity of RIP was synergistic with those of antibiotics for the complete prevention of drug-resistant S. aureus infections.Keywords
This publication has 29 references indexed in Scilit:
- Use of the Quorum‐Sensing Inhibitor RNAIII‐Inhibiting Peptide to Prevent Biofilm Formation In Vivo by Drug‐ResistantStaphylococcus epidermidisThe Journal of Infectious Diseases, 2003
- Prevention of Staphylococcus aureus biofilm on dialysis catheters and adherence to human cellsKidney International, 2003
- Biofilms: Survival Mechanisms of Clinically Relevant MicroorganismsClinical Microbiology Reviews, 2002
- RNAIII inhibiting peptide (RIP) inhibits agr-regulated toxin productionPeptides, 2001
- Functional Study of Antibodies against a Fibrogenin‐Binding Protein inStaphylococcus epidermidisAdherence to Polyethylene CathetersThe Journal of Infectious Diseases, 2001
- Detection of Differential Gene Expression in Biofilm-Forming versus Planktonic Populations of Staphylococcus aureus Using Micro-Representational-Difference AnalysisApplied and Environmental Microbiology, 2001
- Infectious complications of the hemodialysis accessKidney International, 2001
- Coagulase-Negative Staphylococci: Role as PathogensAnnual Review of Medicine, 1999
- The Involvement of Cell-to-Cell Signals in the Development of a Bacterial BiofilmScience, 1998
- The critical relationship of antibiotic dose and bacterial contamination in experimental infectionJournal of Surgical Research, 1992