Growth Hormone Treatment in Noonan Syndrome: Report of Four Cases Who Reached Final Height
- 1 January 1995
- journal article
- clinical trial
- Published by S. Karger AG in Hormone Research
- Vol. 44 (4) , 164-167
- https://doi.org/10.1159/000184618
Abstract
Final height of 4 patients with Noonan syndrome and short stature treated with growth hormone (GH) is reported. Four prepubertal girls (chronological age 12.3-15.1 years, bone age 11.0-11.5 years) were treated with recombinant human growth hormone (0.5 IU/kg/week s.c.) for at least 3 years. Stimulated GH secretion was normal, spontaneous nocturnal GH secretion was low in 1 patient. Final height, as standard deviation score according to Ranke-specific standards for Noonan syndrome, improved in 3 patients and 2 of them exceeded their corrected midparental height.Keywords
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