ENZYMIC BASIS FOR CYCLIC-GMP ACCUMULATION IN DEGENERATIVE PHOTORECEPTOR CELLS OF MOUSE RETINA

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 2  (3) , 139-148
Abstract
The activities of guanylate cyclase, cyclic GMP phosphodiesterase and 5''-nucleotidase were measured during postnatal development in retinas of control and C3H/HeJ mice. In control retina each of these enzyme activities increased in conjunction with photoreceptor cell differentiation and maturation. In C3H retina guanylate cyclase and 5''-nucleotidase activities increased with photoreceptor cell development and decreased with photoreceptor cell death. The activity of a class of cyclic GMP phosphodiesterase which distinguishes the photoreceptor cells of control mice and those of several other species was not demonstrable in the retina of C3H mice at any age. The deficiency in cyclic GMP phosphodiesterase activity may account for the accumulation of cyclic GMP which occurred in the C3H photoreceptor cells before they degenerate.

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