Abstract
THE case reported below describes an unusual phenomenon in diabetes: the periodic obligatory abandonment of insulin therapy. As far as I can determine, no comparable case has been reported in the literature.Case ReportE.M., a 34-year-old married woman, has had diabetes since early childhood. For many years her daily insulin requirement has been in the range of 140 to 180 units of protamine zinc insulin. This dose is administered at night and is occasionally supplemented by a small dose of crystalline insulin. She has adhered faithfully to her prescribed diet, avoiding carbohydrate sprees except under the conditions described below. . . .

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